Publicaciones académicas
- Supplementary Figure S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708061.
- Supplementary Figure S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708058.
- Supplementary Table S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708055.
- Supplementary Table S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708052.
- Supplementary Table S3 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708049.
- Supplementary Table S4 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708046.
- Supplementary Table S5 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708043.
- Supplementary Table S6 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.30708040.
- Targeting prostate cancer by new bispecific monocyte engager directed to prostate-specific membrane antigen. PLOS ONE. https://doi.org/10.1371/journal.pone.0307353.
- Data from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.c.6960458.v1.
- Data from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.c.6960458.
- Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-23-0215.
- Supplementary Data Figure Legend from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710081.v1.
- Supplementary Data Figure Legend from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710081.
- Supplementary Figure 1 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710078.
- Supplementary Figure 1 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710078.v1.
- Supplementary Figure 2 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710075.v1.
- Supplementary Figure 2 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710075.
- Supplementary Figure 3 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710072.v1.
- Supplementary Figure 3 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710072.
- Supplementary Figure 4 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710069.
- Supplementary Figure 4 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710069.v1.
- Supplementary Figure 5 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710066.v1.
- Supplementary Figure 5 from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710066.
- Supplementary Figure 6 A_B from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710063.v1.
- Supplementary Figure 6 A_B from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710063.
- Supplementary Figure 6 C_D from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710060.v1.
- Supplementary Figure 6 C_D from Radiotherapy-induced Immune Response Enhanced by Selective HDAC6 Inhibition. https://doi.org/10.1158/1535-7163.24710060.
- Data from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.c.6533083.v1.
- Data from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.c.6533083.
- Supplementary Figure S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490047.v1.
- Supplementary Figure S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490047.
- Supplementary Figure S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490044.v1.
- Supplementary Figure S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490044.
- Supplementary Table S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490041.v1.
- Supplementary Table S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490041.
- Supplementary Table S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490038.
- Supplementary Table S2 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490038.v1.
- Supplementary Table S3 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490035.v1.
- Supplementary Table S3 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490035.
- Supplementary Table S4 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490032.v1.
- Supplementary Table S4 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490032.
- Supplementary Table S5 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490029.v1.
- Supplementary Table S5 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490029.
- Supplementary Table S6 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490026.v1.
- Supplementary Table S6 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. https://doi.org/10.1158/1078-0432.22490026.
- Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-22-2340.
- Author Correction: Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Scientific Reports. https://doi.org/10.1038/s41598-021-04066-1.
- Enhancing Therapeutic Approaches for Melanoma Patients Targeting Epigenetic Modifiers. Cancers. https://doi.org/10.3390/cancers13246180.
- Editorial: Genetic and Epigenetic Control of Immune Responses. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.775101.
- Phase I Study of Entinostat in Combination with Enzalutamide for Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer. The Oncologist. https://doi.org/10.1002/onco.13957.
- Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2020.577571.
- Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.0c00567.
- CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma. Translational Oncology. https://doi.org/10.1016/j.tranon.2020.100823.
- Actualización general de inmunoterapia en cáncer. Revista médica de Chile. https://doi.org/10.4067/s0034-98872020000700970.
- HDAC6 Plays a Noncanonical Role in the Regulation of Antitumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-19-3738.
- Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Scientific Reports. https://doi.org/10.1038/s41598-020-60409-4.
- Indocyanine Green-Nexturastat A-PLGA Nanoparticles Combine Photothermal and Epigenetic Therapy for Melanoma. Nanomaterials. https://doi.org/10.3390/nano10010161.
- Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20092241.
- Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Scientific Reports. https://doi.org/10.1038/s41598-019-51403-6.
- Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.9b00946.
- Epigenetic therapy for ovarian cancer: promise and progress. Clinical Epigenetics. https://doi.org/10.1186/s13148-018-0602-0.
- Functional Analysis of HDACs in Tumorigenesis. Methods in Molecular Biology. https://doi.org/10.1007/978-1-4939-9434-2_17.
- Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Scientific Reports. https://doi.org/10.1038/s41598-019-42237-3.
- Phase I trial of histone deacetylase inhibitor panobinostat in addition to glucocorticoids for primary therapy of acute graft-versus-host disease. Bone Marrow Transplantation. https://doi.org/10.1038/s41409-018-0163-z.
- Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia. Blood Advances. https://doi.org/10.1182/bloodadvances.2018020065.
- Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.1A0415-176RRR.
- Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.7b00223.
- T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood. https://doi.org/10.1182/blood-2016-08-731505.
- Tet-Mediated DNA Demethylation Is Required for SWI/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.00177-17.
- Erratum to: Functional Analysis of Histone Deacetylase 11 (HDAC11). Methods in Molecular Biology. https://doi.org/10.1007/978-1-4939-3667-0_22.
- Essential role of HDAC6 in the regulation of PD‐L1 in melanoma. Molecular Oncology. https://doi.org/10.1016/j.molonc.2015.12.012.
- Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignancies. Methods in Molecular Biology. https://doi.org/10.1007/978-1-4939-3667-0_10.
- Functional Analysis of Histone Deacetylase 11 (HDAC11). Methods in Molecular Biology. https://doi.org/10.1007/978-1-4939-3667-0_11.
- Preparation and Biochemical Analysis of Classical Histone Deacetylases. Methods in Enzymology. https://doi.org/10.1016/bs.mie.2016.04.005.
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-15-0077-T.
- Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function. Molecular Immunology. https://doi.org/10.1016/j.molimm.2014.08.002.
- Ligand-Independent EPHA2 Signaling Drives the Adoption of a Targeted Therapy–Mediated Metastatic Melanoma Phenotype. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-14-0293.
- Targeting histone deacetylase 6 mediates a dual anti‐melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular Oncology. https://doi.org/10.1016/j.molonc.2015.04.002.
- A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1302778.
- c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease. Molecular Cell. https://doi.org/10.1016/j.molcel.2014.08.013.
- Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Molecular Immunology. https://doi.org/10.1016/j.molimm.2014.02.019.
- Epigenetic Regulation of a Brain-specific Glycosyltransferase N-Acetylglucosaminyltransferase-IX (GnT-IX) by Specific Chromatin Modifiers. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M114.554311.
- Molecular Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-specific T-cell Tolerance. Tumor-Induced Immune Suppression. https://doi.org/10.1007/978-1-4899-8056-4_15.
- Epigenetic Approaches. Cancer Immunotherapy. https://doi.org/10.1016/B978-0-12-394296-8.00022-1.
- Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nature Immunology. https://doi.org/10.1038/ni.2526.
- The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity. Melanoma Research. https://doi.org/10.1097/CMR.0b013e328364c0ed.
- Modulation of antigen‐presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunology & Cell Biology. https://doi.org/10.1038/icb.2011.96.
- Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm301098e.
- Stat3 Inhibition Augments the Immunogenicity of B-cell Lymphoma Cells, Leading to Effective Antitumor Immunity. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-11-3619.
- Tipifarnib-mediated suppression of T-bet-dependent signaling pathways. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-011-1109-0.
- Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1001101.
- Circumventing Immune Tolerance Through Epigenetic Modification. Current Pharmaceutical Design. https://doi.org/10.2174/138161210790170120.
- Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene. https://doi.org/10.1038/onc.2009.334.
- The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.01023-09.
- Erratum: The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nature Immunology. https://doi.org/10.1038/ni0609-665c.
- SWI/SNF-Independent Nuclease Hypersensitivity and an Increased Level of Histone Acetylation at the P1 Promoter Accompany Active Transcription of the Bone Master Gene Runx2. Biochemistry. https://doi.org/10.1021/bi9004792.
- TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses. Immunology Letters. https://doi.org/10.1016/j.imlet.2009.06.007.
- Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-09-2616.
- The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nature Immunology. https://doi.org/10.1038/ni.1673.
- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance. Tumor-Induced Immune Suppression. https://doi.org/10.1007/978-0-387-69118-3_9.
- Histone Deacetylase 3 Down-regulates Cholesterol Synthesis through Repression of Lanosterol Synthase Gene Expression. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M701719200.
- Chromatin Remodeling and Transcriptional Activity of the Bone-specific Osteocalcin Gene Require CCAAT/Enhancer-binding Protein β-dependent Recruitment of SWI/SNF Activity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M511640200.
- Histone Deacetylase 8 Safeguards the Human Ever-Shorter Telomeres 1B (hEST1B) Protein from Ubiquitin-Mediated Degradation. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.01489-06.
- Histone Deacetylase 8 Safeguards the Human Ever-Shorter Telomeres 1B (hEST1B) Protein from Ubiquitin-Mediated Degradation. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.01971-05.
- Use of nanocrystalline diamond for microfluidic lab-on-a-chip. Diamond and Related Materials. https://doi.org/10.1016/j.diamond.2006.05.014.
- Bone-Specific Transcription Factor Runx2 Interacts with the 1α,25-Dihydroxyvitamin D3 Receptor To Up-Regulate Rat Osteocalcin Gene Expression in Osteoblastic Cells. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.24.20.8847-8861.2004.
- Regulation of the Bone-Specific Osteocalcin Gene by p300 Requires Runx2/Cbfa1 and the Vitamin D3 Receptor but Not p300 Intrinsic Histone Acetyltransferase Activity. Molecular and Cellular Biology. https://doi.org/10.1128/MCB.23.9.3339-3351.2003.
- Reduced CpG methylation is associated with transcriptional activation of the bone‐specific rat osteocalcin gene in osteoblasts*. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.10113.