Cursos que dicta
Pregrado
- Química (Medicina y Tecnología Medica)
- Bioquímica (Kinesiología)
- Ciencias Básicas Aplicadas (Medicina)
Postgrado
- Biología Celular y Molecular Avanzada, MCB
- Biomedicina Celular y Molecular, MCB
- Interacción Genoma y Ambiente, MCB
- Aspectos Inmunológicos en Cáncer, MCB
- Seminario, MCB
- Proyecto de Tesis I, MCB
- Tesis I, MCB
- Epistemología, DCBB y MCB
- Seminario I y II, DCBB
- Tesis I-II-III-IV-V, DCBB
Líneas de investigación
- Inmunoterapia y epigenética en cáncer colorrectal
- Biomarcadores de envejecimiento
- Estudio de citotoxicidad de compuesto naturales | Vigilancia epidemiológica de aguas
Nuestro laboratorio se ha especializado en temáticas de regulación transcripcional, así como en diferentes áreas de la Biología Molecular y Celular. El foco de los proyectos de investigación se centra en dilucidar los procesos que involucran la regulación transcripcional en general, los mecanismos epigenéticos, y los procesos celulares y moleculares involucrados en diferentes procesos del envejecimiento, principalmente en respuesta inmune en cáncer colorectal. Tenemos amplio manejo en técnicas de la biología molecular. Por lo cual, durante el año 2020 formamos parte de la Red Nacional de laboratorios universitario de diagnóstico COVID19, yo como director técnico del laboratorio, y a partir de enero del 2021 se comenzó con la detección de SARS-CoV-2 y otros patógenos y sustancias en aguas residuales, siendo director de la iniciativa. Actualmente, se forma parte del primer consorcio de aguas residuales en Chile y se establecimos el primer centro centinela de vigilancia de aguas residuales de Chile, Centro Centinela Biobío.
Publicaciones académicas
- Dataset of illicit drug consumption during and post COVID-19 through wastewater in a city of Chile. Data in Brief. https://doi.org/10.1016/j.dib.2026.112935.
- Biobio Sentinel: Two years of illicit drug surveillance in South-Central Chile. Journal of Hazardous Materials. https://doi.org/10.1016/j.jhazmat.2026.141142.
- Isolation and Characterization of a Novel Bacteriophage KpCCP1, Targeting Multidrug-Resistant (MDR) Klebsiella Strains. Sci. https://doi.org/10.3390/sci7040157.
- Toxicological Responses of Photosynthetic Genes in Chlorella vulgaris Exposed to Environmentally Relevant Concentrations of TiO2 Nanoparticles. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms262110271.
- SALL2-Mediated Suppression of WNT Signaling Through Transcriptional Control of AXIN2 in Colorectal Cancer Cells. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms26167896.
- Genetic diversity and structure of the commercially important sea cucumber Athyonidium chilensis along the coast of Chile. Conservation Genetics. https://doi.org/10.1007/s10592-025-01679-1.
- Tracking SARS-CoV-2 variants in wastewater in San Pedro de la Paz, Chile. Journal of Water and Health. https://doi.org/10.2166/wh.2024.284.
- Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells. Cell Death & Disease. https://doi.org/10.1038/s41419-024-06591-z.
- Chilean sea cucumber: New potential source of biomolecules with high nutritional value and cytotoxic activity. Journal of Food Composition and Analysis. https://doi.org/10.1016/j.jfca.2023.105906.
- Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells. Molecular Immunology. https://doi.org/10.1016/j.molimm.2023.11.007.
- Toxicity evaluation of Pinus radiata D.Don bark wax for potential cosmetic application. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2023.113896.
- Detección y cuantificación de SARS-CoV-2 en plantas de tratamiento de aguas residuales de diferentes ciudades de Chile: hacia la implementación de una vigilancia centinela permanente. Revista chilena de infectología. https://doi.org/10.4067/s0716-10182022000600690.
- The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2022.1031262.
- The linker histone Hho1 modulates the activity of ATP-dependent chromatin remodeling complexes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. https://doi.org/10.1016/j.bbagrm.2021.194781.
- Evaluation and characterization of a new method of extracting bark wax from Pinus radiata D. Don. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2021.114161.
- Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks. Frontiers in Genetics. https://doi.org/10.3389/fgene.2021.613808.
- Actualización general de inmunoterapia en cáncer. Revista médica de Chile. https://doi.org/10.4067/s0034-98872020000700970.
- A Trichostatin A (TSA)/Sp1-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. https://doi.org/10.1016/j.bbagrm.2018.05.002.
- SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer‐related phenotypes. Molecular Oncology. https://doi.org/10.1002/1878-0261.12308.
- Developmental SALL2 transcription factor: a new player in cancer. Carcinogenesis. https://doi.org/10.1093/carcin/bgx036.
- Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. https://doi.org/10.1016/j.bbagrm.2017.01.002.
- Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin. Cell Death & Disease. https://doi.org/10.1038/cddis.2015.165.
- Nucleosome remodeling by the SWI/SNF complex is enhanced by yeast High Mobility Group Box (HMGB) proteins. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. https://doi.org/10.1016/j.bbagrm.2014.06.014.
- Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress. PLoS ONE. https://doi.org/10.1371/journal.pone.0073817.
- Human CCAAT/Enhancer-Binding Protein β Interacts with Chromatin Remodeling Complexes of the Imitation Switch Subfamily. Biochemistry. https://doi.org/10.1021/bi201593q.
- C/EBPβ binds the P1 promoter of the Runx2 gene and up‐regulates Runx2 transcription in osteoblastic cells. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.22652.
- SWI/SNF-Independent Nuclease Hypersensitivity and an Increased Level of Histone Acetylation at the P1 Promoter Accompany Active Transcription of the Bone Master Gene Runx2. Biochemistry. https://doi.org/10.1021/bi9004792.